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Ibuprofen is nonsteroidal anti-inflammatory drugs (NSAID) that reduces hormones that cause inflammation and pain in the body.
Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).
The combination of ibuprofen and pseudoephedrine is used to treat stuffy nose, sinus congestion, cough, and pain or fever caused by the common cold or flu.
Ibuprofen and pseudoephedrine may also be used for purposes not listed in this medication guide.
Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.
Do not use ibuprofen and pseudoephedrine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) within the past 14 days.
Ibuprofen may cause life-threatening heart or circulation problems such as heart attack or stroke, especially if you use it long term. Do not use this medication just before or after heart bypass surgery (coronary artery bypass graft, or CABG).
Get emergency medical help if you have chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.
Ibuprofen may also cause serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and can occur without warning while you are taking ibuprofen, especially in older adults.
Call your doctor at once if you have symptoms of stomach bleeding such as black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.
Do not take more of this medication than is recommended. An overdose of ibuprofen can cause damage to your stomach or intestines.
Do not use this medication just before or after heart bypass surgery (coronary artery bypass graft, or CABG).
Ibuprofen may cause life-threatening heart or circulation problems such as heart attack or stroke, especially if you use it long term.
Ibuprofen may also cause serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and can occur without warning while you are taking ibuprofen, especially in older adults.
Do not use ibuprofen and pseudoephedrine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.
You should not use this medication if you are allergic to ibuprofen or pseudoephedrine, or if you have:

• a stomach ulcer or active bleeding in your stomach or intestines;
• polyps in your nose; or
• a history of allergic reaction to aspirin or other NSAIDs.

Ask a doctor or pharmacist if it is safe for you to take this medicine if you have:

• a history of stomach ulcers or bleeding;
• heart disease, congestive heart failure, high blood pressure;
• systemic lupus erythematosus (SLE);
• liver or kidney disease;
• a thyroid disorder;
• diabetes;
• enlarged prostate or problems with urination;
• a bleeding or blood clotting disorder; or
• if you smoke.

Taking ibuprofen during the last 3 months of pregnancy may result in birth defects and prolonged labor and delivery. Do not take this medication without medical advice if you are pregnant.
It is not known whether ibuprofen and pseudoephedrine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop taking this medication and call your doctor at once if you have a serious side effect such as:

• chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance;
• bloody, or tarry stools, coughing up blood or vomit that looks like coffee grounds;
• fast, pounding, or uneven heartbeat;
• severe dizziness, anxiety, restless feeling, or nervousness;
• easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms;
• dangerously high blood pressure (severe headache, buzzing in your ears, confusion, chest pain, shortness of breath);
• urinating less than usual or not at all;
• skin rash, severe tingling, numbness, pain, muscle weakness; or
• fever, headache, neck stiffness, chills, increased sensitivity to light, purple spots on the skin, and/or seizure (convulsions).

Less serious side effects may include:

• upset stomach, nausea, heartburn, diarrhea, constipation;
• bloating, gas, loss of appetite;
• warmth, tingling, or redness under your skin;
• dizziness, headache, feeling excited or restless;
• sleep problems (insomnia); or
• mild itching or skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Ask a doctor or pharmacist before using any other cough, cold, or pain medicine. Ibuprofen and pseudoephedrine are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains ibuprofen or pseudoephedrine.
Avoid drinking alcohol. It may increase your risk of stomach bleeding.
Tell your doctor about all other medicines you use, especially:

• a blood thinner such as warfarin (Coumadin, Jantoven);
• steroids (prednisone and others);
• diuretics (water pills), or medicines to treat high blood pressure;
• a beta-blocker such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Dutoprol, Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others;
• an antidepressant such as amitriptyline (Elavil, Vanatrip, Limbitrol), doxepin (Sinequan), nortriptyline (Pamelor), and others; or
• aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others.

This list is not complete and other drugs may interact with ibuprofen and pseudoephedrine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.