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Codeine is a narcotic cough suppressant. It affects the signals in the brain that trigger cough reflex.
Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).
Codeine and phenylephrine is a combination medicine used to treat cough, stuffy nose, and sinus congestion caused by allergies or the common cold.
This medicine will not treat a cough that is caused by smoking, asthma, or emphysema.
Codeine and phenylephrine may also be used for other purposes not listed in this medication guide.
Do not use this medicine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.
Do not use this medicine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.
You should not use codeine and phenylephrine if you are allergic to codeine or phenylephrine.
To make sure this medicine is safe for you, tell your doctor if you have:

• heart disease or high blood pressure;
• asthma, chronic obstructive pulmonary disease (COPD), or other breathing disorder;
• diabetes;
• cough with mucus, or cough caused by emphysema or chronic bronchitis;
• thyroid disorder;
• enlarged prostate or urination problems; or
• blockage in your intestines.

Codeine may be habit-forming. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.
FDA pregnancy category C. It is not known whether codeine and phenylephrine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.
Codeine can pass into breast milk and may harm a nursing baby. The use of codeine by some nursing mothers may lead to life-threatening side effects in the baby. Decongestants may also slow breast milk production. Do not use this medicine without telling your doctor if you are breast-feeding a baby.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using codeine and phenylephrine and call your doctor at once if you have:

• severe dizziness or drowsiness;
• weak or shallow breathing;
• severe restlessness or nervousness;
• severe constipation;
• pounding heartbeats or fluttering in your chest;
• painful or difficult urination; or
• little or no urinating.

Common side effects may include:

• mild drowsiness;
• dryness of your eyes, nose, and mouth;
• blurred vision; or
• nausea, vomiting, diarrhea, constipation.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

This medicine may cause blurred vision or impair your thinking or reactions. Avoid driving or operating machinery until you know how codeine and phenylephrine will affect you.
Avoid drinking alcohol while you are taking this medication.
Ask a doctor or pharmacist before using any other cold, cough, allergy, or sleep medicine. Decongestants and cough suppressants are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains a decongestant or cough suppressant.
Taking this medicine with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects. Ask your doctor before taking codeine and phenylephrine with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.
Other drugs may interact with codeine and phenylephrine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.